When Matthew Perry was rushed to a Los Angeles hospital last week due to an adverse reaction to prescription medication, his rep said the actor was “fine” but the former Friends star had several of his pals worrying.

Although Perry, 35, has struggled with Vicodin and alcohol abuse in the past, his rep says the actor’s 24-hour stay at the hospital “was nothing insidious.”

But friends believe that Perry hasn’t fully adjusted to the end of Chandler Bing. “He is having a hard time going from being on a hit show to having a movie (The Whole Ten Yards) that didn’t do that well,” says a pal of Perry’s. “He sort of feels like he’s a has-been already.”

And with a recent weight loss, “friends are concerned,” says the pal. “He is the thinnest he’s ever been.”

Perry has also grown apart from others, including cocktail-waitress girlfriend Rachel Dunn, who moved from New York to L.A. to be near him, then back, because “they drove each other crazy,” says a source. The couple broke up for a few weeks, then decided to reestablish their long-distance relationship. But finding his footing again “is such a daily frustration,” says a friend.

People.com